Mantle Cell Lymphoma Insights

BTK Inhibitor Resistance and Platelet Count Impact Brexu-Cel Survival

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Latest Research

Pfitzer et al.

(2025)
have investigated a novel treatment strategy for mantle cell lymphoma that involves inhibiting two proteins, BIRC5 and MCL-1.

This method aims to address the issue of drug resistance, which often complicates treatment effectiveness.

Drug resistance occurs when cancer cells adapt and become less responsive to therapies, making management more challenging.

The findings indicate that by targeting these specific proteins linked to cancer cell survival, treatment outcomes could be enhanced.

Researchers believe that focusing on BIRC5 and MCL-1 may lead to the development of more effective therapies for patients who have become resistant to current treatments.

This approach has the potential to result in longer remission periods and improved overall survival rates for individuals affected by mantle cell lymphoma.

Clinical Trials

This is a list of upcoming or ongoing clinical trials that are actively recruiting and have been listed or updated in the last two weeks:

Community News

Lymphoma ActionLymphoma ActionApr 11, 2025

Right now, the Government is developing a national cancer plan for England. Lymphoma Action will be submitting evidence to make sure that lymphoma is a priority for the future and we need to hear your views.

When it comes to your experience of lymphoma, what do you think is most important we tell the Government?

The plan will focus on prevention, early diagnosis, improving patient pathways, treatment, living with and beyond cancer, research, tackling health inequalities and improving outcomes for rarer cancers.

If we can make sure the voices of people affected by lymphoma are heard, together we can make sure lymphoma is a priority in the plan. Please share your thoughts in the comments by 18 April (or click on our profile and send us a message directly if you prefer).

Lymphoma Action Post
The Leukemia & Lymphoma SocietyThe Leukemia & Lymphoma SocietyApr 09, 2025

Have you ever participated in a LLS Light The Night or

LLS Team In Training event?

What was the experience like?

Lymphoma Research FoundationLymphoma Research FoundationApr 11, 2025

#AYACancerAwarenessWeek may be over, but we're focused on adolescent and young adult patients all year round through the convening power of our Adolescent and Young Adult Lymphoma Consortium.

Foundation Scientific Advisory Board member and AYA Consortium co-chair Andrew Evens, DO, MSc (Rutgers Cancer Institute) spoke with attendees like Priyanka Pophali, MD (UW Health l Carbone Cancer Center) at last month's AYA Lymphoma Scientific Workshop about how their work is transforming the treatment landscape and leading to longer, healthier lives for the youngest lymphoma patients.

Learn more about the AYA Lymphoma Consortium: https://lymphoma.org/aboutus/research/scientificmeetings/ayascientificmeeting/

Lymphoma Research Foundation Post

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