Mantle Cell Lymphoma Insights

LV20.19 CAR T-cell therapy achieves 100% response rate in...

April 23, 2025

Latest Research

Hu et al.

(2025) developed an albumin-based nanocomplex (Nano-2025) carrying a BCL-2/xL inhibitor that targets lymphoid organs in Mantle Cell Lymphoma (MCL).

This approach enhances anticancer effects by concentrating the drug in affected tissues while reducing platelet toxicity, a common side effect of conventional treatments.

The findings suggest Nano-2025 could provide a safer, more effective therapy for MCL patients by minimizing damage to healthy cells and improving drug delivery to lymphatic tissues.

The study highlights nanotechnology's potential to enhance treatment efficacy while reducing harmful side effects in aggressive lymphomas (Hu et al., 2025).

Clinical Trials

This is a list of upcoming or ongoing clinical trials that are actively recruiting and have been listed or updated in the last two weeks:

A Pilot "Window-3" Study of Acalabrutinib Plus Rituximab Followed by Brexucabtagene Autoleucel Therapy in Patients With Previously Untreated High-risk Mantle Cell Lymphoma

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies

Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-Degrader

View the full list of clinical trials →

Community News

The Leukemia & Lymphoma SocietyApr 19, 2016

We are saddened by the news of Doris Roberts’ passing. Doris was involved with LLS’s mission in memory of her husband William, who lost his battle to blood cancer.

Lymphoma ActionApr 16, 2025

What are your tips for getting used to being in remission?

The aim of most lymphoma treatments is to send it into remission. There are different types of remission, depending on how much of the lymphoma has gone. For some types of lymphoma, treatment aims to get rid of all of the lymphoma (complete remission). For other types, treatment aims to control the lymphoma and send it into partial remission.

Remission can bring mixed feelings, and some people worry that their lymphoma might come back (relapse). If this happens, your doctors can talk to you about treatment options available to you.

Living with the uncertainty of relapse can be difficult to cope with emotionally – remember that we are here to support you 💜.

Find out more about remission 👉 www.lymphoma-action.org.uk/Remission

Lymphoma Research FoundationApr 15, 2025

Being a self-advocate and an active participant in your treatment plan can help to empower you amid a lymphoma diagnosis. Learn more about what being an advocate for yourself during treatment looks like and ways to better understand your diagnosis and the road ahead: https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options